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A bioactive sol‐gel glass implant for in vivo gentamicin release. Experimental model in Rabbit
Author(s) -
MeseguerOlmo L.,
RosNicolás MJ.,
VicenteOrtega V.,
AlcarazBaños M.,
ClavelSainz M.,
Arcos D.,
Ragel C.V.,
ValletRegí M.,
MeseguerOrtiz Cl.
Publication year - 2006
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.20064
Subject(s) - gentamicin , resorption , biomaterial , in vivo , biocompatibility , bioactive glass , biomedical engineering , implant , gentamicin sulfate , materials science , bone growth , dentistry , chemistry , antibiotics , surgery , medicine , pathology , biology , biochemistry , microbiology and biotechnology , metallurgy
Biomaterial pieces with osteogenic properties, suitable for use in the treatment of bone defects, were synthesized. The materials, which avoid bone infections, are exclusively composed of gentamicin sulfate and bioactive SiO 2 ‐CaO‐P 2 O 5 sol‐gel glass (synthesized previously), and were manufactured by means of uniaxial and isostatic pressure of the mixed components. After implanting the pieces into rabbit femur, we studied (1) antibiotic release, determining the concentration in proximal and distal bone, liver, kidney, and lung as a function of time, and (2) bone growth as a consequence of the glass reactivity in the biological environment. The results demonstrated that the implants are good carriers for local gentamicin release into the local osseous tissue, where they show excellent biocompatibility and bone integration. Moreover, these implants are able to promote bone growth during the resorption process. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 24:454–460, 2006