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PT‐12, a putative ras‐activated proliferation‐dependent gene, is expressed in patellar tendon and not in anterior cruciate ligament
Author(s) -
Goomer R. S.,
Maris T.,
Ostrander R.,
Amiel D.
Publication year - 1999
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100170519
Subject(s) - anterior cruciate ligament , patellar tendon , tendon , ligament , anatomy , biology , medicine
Abstract We describe a gene (PT‐12) that is expressed in the patellar tendon and not in the anterior cruciate ligament. We used a recently developed polymerase chain reaction‐based subtractive cDNA analysis to discover genes that are overexpressed in the patellar tendon but not expressed in the anterior cruciate ligament; the long‐term objective was to find genes that are central to the self‐repair of the patellar tendon, in contrast with the inability of the anterior curciate ligament to launch a repair response following injury. PT‐12 is a homologue of human S2 or mouse LLRep3 ribosomal genes, which are known to be overexpressed in highly proliferating cells. This study opens a new vista to the development of techniques and reagents to study the differences between two periarticular tissues (i.e., the patellar tendon and anterior cruciate ligament) that differ primarily in their ability to self‐repair.