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Pyridinoline in relation to ultimate stress of the patellar tendon during healing: An animal study
Author(s) -
Chan Barbara P.,
Fu S. C.,
Qin L.,
Rolf C.,
Chan K. M.
Publication year - 1998
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100160512
Subject(s) - pyridinoline , tendon , patellar tendon , medicine , surgery , biology , biochemistry , alkaline phosphatase , osteocalcin , enzyme
The ultimate stress of the central one‐third of the patellar tendon was studied in a gap wound‐healing model in the rat. The specimens were also analyzed for collagen and nonreducible crosslinks, as measured by hydroxyproline and pyridinoline content, respectively. Thirty days after injury, the ultimate stress of the healing patellar tendon was restored to an average of 71% of the control value and remained constant over time. The pyridinoline content of the healing tendon was twice the control value by 30 days after injury and reached a plateau; however, the hydroxyproline content did not change significantly over time. Stepwise regression analysis demonstrated that pyridinoline was a better biochemical marker for ultimate stress than was hydroxyproline. The current study provides insights into the functional behaviour of the healing patellar tendon by establishing the relationship between the two biochemical components and the ultimate stress of the healing patellar tendon. This study also suggests the possibility of using pyridinoline content as an indirect marker of the ultimate stress because in vivo assessment is impossible.