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Skeletal anomalies in the adriamycin‐exposed prenatal rat: A model for VATER association
Author(s) -
Kotsios Christine,
Merei Jamal,
Hutson John M.,
Graham H. Kerr
Publication year - 1998
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100160109
Subject(s) - atresia , in utero , medicine , anal atresia , anatomy , fetus , dysplasia , pathology , biology , pregnancy , genetics
Vertebral and radial anomalies are prominent features of VATER v ertebral defects, a norectal anomaly, t acheo e sophageal fistula with esophageal atresia, and r adial dysplasia association. It has been shown that exposure of the rat fetus to adriamycin produces a spectrum of anomalies, including esophageal atresia and other features of VATER association. We aimed to document the skeletal defects found in rats exposed to teratogenic doses of adriamycin in utero . Vertebral, rib. and limb anomalies were found in 54, 54, and 35% of these examined fetuses, respectively. The range of bone lesions seen in this animal model was similar to the range of lesions seen in infants born with VATER association.