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Staphylococcal septic arthritis: Antibiotic and nonsteroidal anti‐inflammatory drug treatment in a rabbit model
Author(s) -
Smith R. Lane,
Kajiyama G.,
Schurman D. J.
Publication year - 1997
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100150619
Subject(s) - medicine , septic arthritis , antibiotics , naproxen , staphylococcus aureus , synovial fluid , arthritis , cartilage , drug , infectious arthritis , pharmacology , osteoarthritis , microbiology and biotechnology , pathology , bacteria , genetics , alternative medicine , anatomy , biology
This study evaluated the effects of combining antibiotic therapy with the application of a nonsteroidal anti‐inflammatory drug on the degradation of articular cartilage for an animal model of Staphylococcal septic arthritis. Rabbits were infected intra‐articularly with Staphylococcus aureus . Antibiotic treatment started 18 hours after infection and continued for 7 days. Treatment with the nonsteroidal anti‐inflammatory drug naproxen sodium started 24 hours before infection and continued for either 3 or 7 weeks. The cartilage matrix of uninfected and infected knees was quantified by analysis of glycosaminoglycan and collagen content. Three weeks after infection, the combined treatment of the nonsteroidal anti‐inflammatory drug and antibiotics reduced the loss of glycosaminoglycan and collagen from the cartage of the infected knee by 15 and 30%, respectively, compared with antibiotic treatment alone. Continuing treatment with naproxen sodium for 7 weeks reduced the loss of collagen by 50% when compared with antibiotic treatment alone. The longer period of treatment with naproxen sodium showed little further effect on the loss of glycosaminoglycan than that observed for the 3‐week treatment. Treatment with this drug and antibiotics reduced swelling of the knee and levels of prostaglandin E 2 in the synovial fluid. The data support the hypothesis that decreasing post‐infectious inflammation by adding the drug to a standard antibiotic regimen reduces cartilage damage from Staphylococcal septic arthritis.