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Biochemical and density assessment of the new bone in late remodeling after callus distraction
Author(s) -
Lammens Johan,
Aerssens Jeroen,
Nijs Jos,
Mokassa Luc,
Dequeker Jan,
Bouillon Roger,
Fabry Guy
Publication year - 1997
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100150311
Subject(s) - hydroxyproline , callus , osteocalcin , chemistry , tibia , bone mineral content , fractionation , endocrinology , bone mineral , medicine , anatomy , biology , biochemistry , alkaline phosphatase , chromatography , botany , osteoporosis , enzyme
Biochemical changes in a canine bone‐lengthening model were characterized 5 months after surgery. The mineral content and the total amount of EDTA‐extractable noncollagenous proteins, insulin‐like growth factor‐I, and osteocalcin were determined for the lengthened callus, and a gradient density fractionation analysis of bone powder particles was performed. The results were compared with two other areas of the lengthened tibia and one region of the contralateral tibia. The mineral and osteocalcin contents showed significant decreases, whereas the hydroxyproline concentration was significantly increased. Neither the insulinlike growth factor‐I content nor the concentration of EDTA‐extractable proteins was significantly different in any of the examined regions.