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Relative effects of wound healing and mechanical stimulus on early bone response to porous‐coated implants
Author(s) -
Hollister Scott J.,
Guldberg Robert E.,
Kuelske Cheryl L.,
Caldwell Nancy J.,
Richards Mark,
Goldstein Steven A.
Publication year - 1996
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100140422
Subject(s) - x ray microtomography , implant , mechanical load , biomedical engineering , materials science , bone healing , wound healing , biomechanics , dentistry , anatomy , medicine , surgery , composite material , radiology
We hypothesized that early bone adaptation to well fixed porous‐coated implants is influenced more by wound healing than by mechanical loading. To test this hypothesis, two groups of dogs with identical, hydraulically controlled porous‐coated implants interference fit within distal femoral trabecular bone were used. One group had no load; the other had 35 N of load applied to the implants. At 5 weeks after surgery, the resulting adaptation of bone around the implants was quantified on a cellular basis by cytochemical analysis of type‐I procollagen synthesis and on a structural basis using three‐dimensional micro‐computed tomography imaging. The percentage of trabecular surfaces covered by osteoblasts expressing type‐I procollagen was significantly increased in bone surrounding the implant in both groups compared with contralateral control bone tissue. There was no difference between the groups with no load or 35 N of load. In addition, measures of trabecular bone structure did not differ significantly between the load and no‐load groups. Taken together, these results suggest that wound healing plays a much greater role in the early response of bone to well fixed porous‐coated implants than does mechanical stimulus.