Premium
Associations and dissociations between serum bone gla protein and alkaline phosphatase in skeletal metabolism
Author(s) -
Parthemore J. G.,
Burton D. W.,
Deftos L. J.
Publication year - 1993
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100110509
Subject(s) - endocrinology , alkaline phosphatase , medicine , osteoblast , calcitonin , bone remodeling , menstrual cycle , chemistry , hormone , enzyme , biochemistry , in vitro
Abstract Serum bone Gla protein (BGP) and alkaline phosphatase (AP) activity were compared for the assessment of skeletal status in 11 normal pregnant women, 12 normal women on days 3 and 13 of the menstrual cycle, five postmenopasual women before and after 1 month of treatment with ethinyl estradiol (20 μg/day), five patients with cancer and hypercalcemia during treatment with calcitonin, and one patient with Paget disease during treatment with Plicamycin. BGP and AP correlated with each other only in the pregnant women. In all other circumstances, there was no correlation between these two serum osteoblast products. Furthermore, there were condisitions in which the two measurements became discordant. These studies demonstrate that BGP and AP commonly are dissociated when used as measurements of skeletal status. Although both are osteoblast products, BGP and AP probably reflect different aspects of osteoblast differentiation and function.