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Partial pressures of oxygen and carbon dioxide in bone and their correlation with bone‐blood flow: Effect of decreased arterial supply and venous congestion on intraosseous oxygen and carbon dioxide in an animal model
Author(s) -
Kiær Thomas,
Dahl Benny,
Lausten Gunnar
Publication year - 1992
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100100609
Subject(s) - carbon dioxide , oxygen , blood flow , partial pressure , venous blood , anesthesia , chemistry , medicine , cardiology , organic chemistry
Pathological changes in bone have been related to a preceding impediment of the arterial or venous bone circulation and hypoxia. In this study, we analyzed the feasibility of mass spectrometry in measuring intraosseous oxygen and carbon dioxide. The partial pressures were also measured in intraosseous blood samples, and blood flow in bone was measured with the radioactive microspheres technique. The average partial pressure of oxygen in the lateral femoral condyle was 34 ± 1.6 mm Hg when measured in intraosseous blood samples and 36.3 ± 2.3 mm Hg when measured with the on‐line mass spectrometer, with significant correlation between the methods. The absolute value of the partial pressure of carbon dioxide measured in situ with mass spectrometry was correlated with the value in the withdrawn blood. There was no significant difference in partial pressures of oxygen and carbon dioxide between the two sides or between repetitive measurements. Arterial occlusion resulted in severe hypoxia, whereas more moderate changes followed venous occlusion.