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The effects of ischemia on long bone vascular resistance
Author(s) -
Davis Timothy R. C.,
Wood Michael B.
Publication year - 1991
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100090615
Subject(s) - ischemia , resistance (ecology) , cardiology , medicine , biology , ecology
An in vitro canine tibia model was used to assess the effects of 48 h of hypothermic (4°C) ischemia on bone vascular resistance and on responsiveness of intraosseous blood vessels to circulating norepinephrine. Three groups of bones were studied: Group I ( n = 11), 48 h hypothermic ischemia; Group II ( n = 11), 48 h hypothermic ischemia with pretreatment with allopurinol and oxypurinol; and Group III ( n = 10), no ischemia. Resting vascular resistance in both ischemic groups (79 and 74 mmHg/ml/min) was significantly higher ( p < 0.0001) than in the nonischemic group (22 mmHg/ml/min). Effects of norepinephrine on vascular resistance were significantly greater in both ischemic groups ( p < 0.004). In all three groups, acetylcholine infusion attenuated the increases in perfusion pressure caused by norepinephrine. This demonstrates secretion of endothelial‐mediated relaxing factors (EDRF) and prostaglandin for up to 48 h of hypothermic ischemia. As no significant differences were detected between the two ischemic groups, this study failed to demonstrate any protective effect of xanthine oxidase inhibitors.