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Regional blood flow and strontium‐85 incorporation rate in the rat hindlimb skeleton
Author(s) -
Kirkeby Ole J.,
BergLarsen Trine
Publication year - 1991
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100090612
Subject(s) - skeleton (computer programming) , hindlimb , strontium , blood flow , anatomy , chemistry , biology , medicine , organic chemistry
Regional distribution of radioactive microspheres and 85 Sr incorporation rate in the os ilium, femur, and tibia were determined in 44 rats. In 15 additional animals, regional blood flow was measured with the reference sample technique. Highest numbers of microspheres were found in the distal femoral and proximal tibial metaphyses. Highest blood flow rates were found in the os ilium, the caput femoris, and distal femoral and proximal tibial metaphyses. The diaphyses and epiphyses of the femur and tibia had a relatively lower perfusion. The regional 85 Sr incorporation rate was correlated ( r = 0.67) to the regional distribution of the microspheres. The dispersion of the data was large and this was mainly due to biological variation. The results describe the regional distribution of blood flow in the rat hindlimb and demonstrate a close association between blood flow and mineral turnover in normal rat skeletal tissue as shown by the correlation between microsphere and 85 Sr incorporation rate distribution.