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Physeal reconstruction using tissue donated from early postnatal limbs in a murine model
Author(s) -
Cundy Peter J.,
Jofe Michael,
Zaleske David J.,
Ehrlich Michael G.,
Mankin Henry J.
Publication year - 1991
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100090307
Subject(s) - transplanting , stage (stratigraphy) , anatomy , transplantation , epiphysis , biology , medicine , surgery , paleontology , seedling , horticulture
Physeal reconstruction was performed in a murine model by transplanting corresponding postanatal tissue from 4‐day‐old C57B mice to resection defects. The site of the reconstruction, the murine distal femoral epiphysis, is completely cartilaginous and avascular at this stage of development. The tissue transplanted into the defect was demonstrated to have high kinetic activity by its incorporation of titriated thymidine. The physeal reconstruction as performed restored only 25% of normal growth. While transplanting cell populations is feasible, the method will require a great deal of work before clinical application.