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Heterogeneity of blood flow in tibial cortical bone: An experimental investigation using microspheres
Author(s) -
Willans S. M.,
McCarthy I. D.
Publication year - 1991
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100090203
Subject(s) - microsphere , periosteum , diaphysis , cortex (anatomy) , blood flow , cortical bone , anatomy , biomedical engineering , deposition (geology) , materials science , femur , chemistry , biology , surgery , medicine , paleontology , chemical engineering , neuroscience , sediment , engineering
The distribution of tibial blood flow was measured by injecting approximately (600–1000) X 10 3 15 μ microspheres, labelled with either tin‐113 ( 113 Sn) or cobalt‐57 ( 57 Co) into femoral arteries of five mature greyhounds. The diaphyseal cortex, stripped of periosteum and devoid of marrow, was sawn into 40 pieces (10 transverse sections X 4 anatomical quarters/section). Relative deposition densities of the 113 Sn microspheres in 40 pieces of cortex were found. These values, together with their associated masses, proved, from a statistical point of view, that flow rate heterogeneity was substantial in the diaphysis. In particular, for the diaphyseal cortex, distribution of relative deposition densities (flow rates) in six bones was found to be positively‐skewed with a relative dispersion ((SD/mean) x 100) of ∼40%.