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A model of Staphylococcus aureus bacteremia, septic arthritis, and osteomyelitis in chickens
Author(s) -
Daum Robert S.,
Davis W. Hodges,
Farris K. Barton,
Campeau Richard J.,
Mulvihill Denise M.,
Shane Simon M.
Publication year - 1990
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100080605
Subject(s) - septic arthritis , bacteremia , osteomyelitis , staphylococcus aureus , medicine , inoculation , arthritis , microbiology and biotechnology , micrococcaceae , immunology , biology , antibiotics , bacteria , genetics
We studied the occurrence, magnitude, and kinetics of bacteremia and the resultant osteomyelitis and septic arthritis in an avian model of Staphylococcus aureus infection. Thirty‐day‐old male broiler chicks were inoculated i.v. with 10 5 , 10 6 , or 10 7 cfu of strain Duntravis, a β‐hemolytic, coagulaseproducing, capsular type 8 isolate from the synovial fluid of a 2‐year‐old black boy. Bacteremia occured in 80%, 90%, and 100% of animals inoculated with 10 5 , 10 6 , or 10 7 cfu, respectively. The magnitude of bacteremia in surviving, bacteremic animals increased for 96 hours after inoculation and then decreased after a plateau phase. Osteomyelitis and septic arthritis occurred only in chicks that were continuously bacteremic. The occurrence of osteomyelitis was uniform among continuously bacteremic animals and developed 1 to 23 hours after inoculation. Chickens are susceptible to systemic infections with S. aureus . Bacteremia, osteomyelitis, and septic arthritis may be induced in healthy chickens without prior manipulations that depress their resistance.