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The effect of a brain lesion on bone healing
Author(s) -
Spencer R. F.,
Bullock R.,
Cooper K.,
Norman R. J.,
Becker P. J.
Publication year - 1990
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100080505
Subject(s) - spasticity , spastic , lesion , medicine , anatomy , surgery , anesthesia , physical medicine and rehabilitation , cerebral palsy
Using a feline model, the effects of stereotaxic brain lesions producing unilateral spasticity on bilateral fibular osteotomies were observed. Healing in spastic limbs occurred with more new bone formation than on the contralateral (control) side. Union appeared to be slightly faster in spastic limbs. Histomorphometric analysis of resected fibular specimens following union revealed little difference between spastic and non‐spastic limbs. When these brain‐lesioned animals were compared with a group with identical osteotomies but no brain lesions in respect of various systemic biochemical and endocrine parameters, no differences were found.