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Effects of variation in systemic blood pressure on intraosseous pressure, PO 2 , and PCO 2
Author(s) -
Kiær Thomas,
Grønlund Jørgen,
Jensen Birgit,
Svalastoga Eiliv
Publication year - 1990
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100080419
Subject(s) - hypovolemia , pco2 , systemic circulation , blood pressure , blood flow , anesthesia , medicine , cardiology , chemistry
Several regulatory mechanisms have been shown to influence the intraosseous circulation. The influence of general hypovolemia on bone circulation and possible regulatory effects were investigated by recording the intraosseous pressure and PO 2 and PCO 2 continuously by mass spectrometry in rabbits. Hypovolemia was induced by repeated bleedings. The intraosseous and arterial pressures were found to be linearly related. The intraosseous PO 2 already decreased after the first step of bleeding and decreased more than 50% of the initial value after an average blood loss of 40 ml. The intraosseous PCO 2 showed an opposite pattern. The experimental PO 2 vs. arterial pressure curves were similar to curves obtained by a computer simulation that assumes the blood flow to be proportional to the intraosseous pressure.