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Pulsing direct current‐induced repair of articular cartilage in rabbit osteochondral defects
Author(s) -
Lippiello Louis,
Chakkalakal Dennis,
Connolly John F.
Publication year - 1990
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100080216
Subject(s) - safranin , cartilage , hyaline cartilage , pannus , anatomy , regeneration (biology) , femoral condyle , subchondral bone , biomedical engineering , materials science , medicine , pathology , articular cartilage , osteoarthritis , biology , microbiology and biotechnology , arthritis , alternative medicine
Osteochondral defects in the distal femoral condyles of rabbits exposed to a pulsing direct current exhibits an enhanced quality of repair. The signal, with a peak value of 2 μA repeating at 100 Hz, imposed an electric field in the tissue of 20–60 mV/cm 2 . Maximum efficacy was seen with a shorter period of exposure (40 vs. 160h) initiated 48 h after surgery for 4 h/day. Repair tissue originated primarily from metaplasia of subchondral elements although hyperplasia of pre‐existing chondrocytes at the margins of the defect could be detected. Defects in treated joints contained Safranin O staining material that was histologically similar to a disorganized hyaline cartilage. Central areas of the defects in control animals contained Safranin O‐negative material that generally extruded over the surface as a pannus. The edges of nontreated defects also had characteristics of cartilaginous healing, stressing the importance of using serial sectioning techniques in this model of cartilage repair.

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