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Production of catabolin by synovium from an experimental model of osteoarthritis
Author(s) -
Sabiston C. Paul,
Adams Mark E.
Publication year - 1989
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100070409
Subject(s) - osteoarthritis , medicine , pathology , alternative medicine
Abstract Catabolic factors from synovium, or catabolins, may be important in the pathogenesis of osteoarthritis. The synovial production of catabolin in osteoarthritis was studied using the experimental model of osteoarthritis induced by section of the anterior cruciate ligament. At 1, 4, and 32 weeks after operation, the synovium was harvested, cultured, and the synovial conditioned medium assayed for catabolic activity. The synovial conditioned medium from the operated joints was significantly more capable of inducing cartilage destruction (p < 0.05) than was the synovial conditioned medium from the unoperated knees. However, when the results were expressed relative to the weight of synovium, the differences were not significant. These results suggest that the increased production of catabolic synovial factors in early experimental osteoarthritis is probably a result of the synovial hypertrophy.