Premium
“Benign” metastasizing giant cell tumor: Evaluation of nuclear DNA patterns by flow cytometry
Author(s) -
Scott Steven M.,
Pritchard Douglas J.,
Unni K. Krishnan,
Rainwater Leslie M.,
Lieber Michael M.
Publication year - 1989
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100070402
Subject(s) - flow cytometry , nuclear dna , pathology , ploidy , dna , giant cell , cell , biology , cytometry , microbiology and biotechnology , medicine , genetics , mitochondrial dna , gene
Abstract Nuclear deoxyribonucleic acid (DNA) ploidy was determined by flow cytometry for nine histologically benign giant cell tumors that developed systemic metastases and for eight tumors that did not metatasize. Specimens from the primary tumor, local recurrences, and pulmonary metastases were evaluated. No feature of the DNA ploidy pattern was identified to distinguish giant cell tumors that metastasized from those did not. The mean percentage of diploid (G0/G1 peak, 2C) cells was 81% in the metastasizing group and 80% in the nonmetastasizing group. The DNA ploidy pattern of the primary tumors was not different from that of their metastases. No DNA aneuploid patterns were observed among the benign tumors.