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Recovery of the dog quadriceps after 10 weeks of immobilization followed by 4 weeks of remobilization
Author(s) -
Lieber Richard L.,
McKeeWoodburn Thalia,
Gershuni David H.
Publication year - 1989
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100070313
Subject(s) - quadriceps muscle , quadriceps femoris muscle , atrophy , connective tissue , anatomy , significant difference , skeletal muscle , fiber type , analysis of variance , medicine , muscle fibre , chemistry , pathology , isometric exercise
Skeletal muscle fiber areas were measured in three heads of the dog quadriceps after 10 weeks of immobilization followed by 4 weeks of remobilization. Two‐way analysis of variance demonstrated a significant decrease in both type 1 (p < 0.005) and type 2 (p < 0.001) fiber area. However, there was no significant difference among the three heads of the quadriceps (p > 0.2). Although muscle fiber areas had not returned to control levels following remobilization, the area fraction of perimysial and epimysial connective tissue was not significantly different from control values (p > 0.15). These data suggest that although the degree of muscle atrophy following 10 weeks of immobilization is severe and muscle specific, following 4 weeks of remobilization, muscles uniformly recover to about 70% of control values.