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Effects of indomethacin on bone ingrowth
Author(s) -
Keller J. C.,
Trancik T. M.,
Young F. A.,
Mary E. St.
Publication year - 1989
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100070105
Subject(s) - implant , animal model , medicine , placebo , chemistry , surgery , pathology , alternative medicine
The effects of indomethacin, a nonsteriodal antiinflammatory agent, on bone ingrowth were studied using a rabbit animal model and a porous cylindrical implant system. Bone ingrowth was found to be independent of pore size in the range tested (0.6–1.0 mm). In the control (placebo‐treated) group, there was a significant increase in bone ingrowth between the 2‐ and 8‐week groups of animals. However, in the indomethacin‐treated group, there was no increase in bone ingrowth with time.