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Synovial membrane and cartilage changes in experimental osteoarthrosis
Author(s) -
Lukoschek M.,
Schaffler M. B.,
Burr D. B.,
Boyd R. D.,
Radin E. L.
Publication year - 1988
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100060403
Subject(s) - cartilage , chondrocyte , cartilage damage , synovial membrane , articular cartilage , instability , medicine , osteoarthritis , anatomy , pathology , chemistry , inflammation , physics , alternative medicine , mechanics
The Hulth instability model was performed on 25 rabbit knee joints. Electron‐microscopic, light‐microscopic, and histomorphometric data demonstrated consistent chondrocyte alterations and cartilage destruction. The comparison between operated, sham, and control knees shows that surgical intervention without surgically induced instability is followed by changes in the synovial membrane and cartilage. The cartilage destruction is preceded by a synovial reaction, suggesting that the inflammatory response has an important role in the onset of cartilage damage in this model. The damage was more severe in the experimental knees, suggesting that mechanical instability is also a factor in cartilge destruction.