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Transient synovitis of the hip in the child: Increased levels of proteoglycan fragments in joint fluid
Author(s) -
Lohmander L. S.,
Wingstrand H.,
Heinegård D.
Publication year - 1988
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100060313
Subject(s) - synovitis , proteoglycan , synovial fluid , joint (building) , transient (computer programming) , medicine , arthritis , anatomy , pathology , computer science , structural engineering , osteoarthritis , cartilage , engineering , alternative medicine , operating system
The levels of proteoglycan antigen were measured in joint aspirates from the hip of children with transient synovitis, septic arthritis, Legg‐Calvé‐Perthes' disease and congenital and traumatic dislocation. Significantly increased levles were found in children with transient synovitis and septic arthritis as compared with other conditions. We propose that the proteoglycan antigens in the joint fluid were released from the articular cartilage in a partially degraded form as a result of an increased rate of proteolytic degradation. In transient synovitis, the source of proteolytic activity may be chondrocytes activated by factors released by synovial cells. The release of joint proteoglycan may cause a temporary increase in deformability of the hip cartilage of the child that could be an important pathogenetic mechanism in some of the sequelac of these diseases.