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Kinetic effects of adriamycin and bleomycin on two osteosarcoma models
Author(s) -
Bell D. F.,
Bell R. S.,
Mankin H. J.,
Gebhardt M. C.,
Weltie F.,
O'Brien T.
Publication year - 1988
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100060107
Subject(s) - osteosarcoma , bleomycin , in vivo , cell cycle , in vitro , pharmacology , cancer research , cell growth , thymidine , chemistry , doxorubicin , cell culture , cell , biology , medicine , chemotherapy , biochemistry , microbiology and biotechnology , genetics
Although chemotherapeutic drugs are frequently administered to patient with osteosarcoma, there has been little research into the effect of cytotoxic drugs on osteosarcoma cell biology. The effect of two drugs (Adriamycin and bleomycin) on cell cycle kinetics was investigated in vitro in an established line of human osteosarcoma cells and in vivo using the Dunn osteosarcoma model. The cell cycle changes were consistent with G 2 arrest for both drugs in vivo and in vitro. The alteration in cell cycle distribution was correlated with inhibition of 3 H‐thymidine incorporation in vitro. In vivo, the greater change in cell cycle distribution caused by Adriamycin was reflected in the increased inhibition of tumor growth found with this drug.