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The in vitro effect of gold complexes on bone resorption
Author(s) -
Katz J. M.,
Gray D. H.
Publication year - 1986
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100040207
Subject(s) - auranofin , calvaria , resorption , chemistry , in vitro , bone resorption , hydroxyproline , enzyme , dna synthesis , biochemistry , pharmacology , endocrinology , medicine , rheumatoid arthritis
Mouse calvaria were maintained in organ culture without serum additives. The effects of three gold complexes—aurothioglucose, aurothiomalate, and auranofin—on active bone resorption ( 45 Ca release) and hydroxyproline synthesis were determined. The influence of these compounds on DNA and protein synthesis and lysosomal enzyme release from calvaria was also assessed. All gold complexes reduced bone resorption to some extent, with auranofin being the most potent within a narrow concentration range (10 −6 M ). This concentration of auranofin also significantly inhibited collagen synthesis, although DNA and protein synthesis were unaffected. None of the compounds tested appeared to mediate their action via significant inhibition of lysosmal enzyme release.