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Antibiotic absorption from infected and normal joints using a rabbit knee joint model
Author(s) -
Schurman David J.,
Kajiyama Glen
Publication year - 1985
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100030207
Subject(s) - antibiotics , cefazolin , cefoxitin , gentamicin , absorption (acoustics) , neomycin , kanamycin , amikacin , medicine , staphylococcus aureus , microbiology and biotechnology , biology , materials science , bacteria , genetics , composite material
An understanding of the absorption of antibiotics from joints was investigated comparing intraarticular (i.a.) absorption with intramuscular (i.m.) absorption in rabbit knee mode. The antibiotics investigated were methicillin, cephalothin, cefazolin, cefoxitin, amikacin, neomycin, kanamycin, and gentamicin. Absorption was measured both in animals in which the knee joint was infected with Staphylococcus aureus and in normal animals. The pattern of absorption from infected joints 37% slower than from an i.m. injection. In animals that are not infected i.a. antibiotics are actually absorbed 12% faster than i.m. anitbiotics. Thus, i.a. antibiotics are absorbed rapidly and similarly to i.m. injection and should be included in total dose calculations for antibiotic regimens, especially with regard to their potential toxicity.