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Chemotherapy‐induced alterations in the biomechanics of rat bone
Author(s) -
Pelker Richard R.,
Friedlaender Gary E.,
Panjabi Manohar M.,
Markham Thomas,
Hausman Michael,
Doganis Andrew C.,
McKay Jim
Publication year - 1985
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100030111
Subject(s) - doxorubicin , methotrexate , medicine , biomechanics , torsion (gastropod) , osteotomy , bone healing , surgery , chemotherapy , urology , anatomy
The effects of methotrexate and doxorubicin (Adriamycin) on intact and fractured bone were studied in a rat model. Methotrexate, 0.1 mg/kg i.p., was administered five times a week, or doxorubicin, 1 mg/kg i.v., was given once a week. Animals were killed and evaluated at 4, 8, 12, and 16 weeks after surgical production of a unilateral femoral osteotomy and initiation of the chemotherapeuitic program. Both intact and fractured bones were tested to failure in rapid torsion, and the torque, angular deformation, stiffness, and energy were measured. There was a significant alteration in the strength of the healing osteotomies in doxorubicin‐ and methotrexate‐treated animals compared with the control group. The torsional strength of intact bone was not significantly altered by either drug protocol over the period of this observation.