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Pathogenesis of chronic inflammation in experimental ferritin‐induced arthritis. V. Electron microscopic localization of specific antibodies in the synovial membrane
Author(s) -
Sakata Toshiro,
Ohno Osamu,
Ishikawa Hitoshi,
Hirohata Kazushi,
Cooke T. D. V.
Publication year - 1984
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100020407
Subject(s) - antibody , ferritin , synovial membrane , endoplasmic reticulum , arthritis , inflammation , pathology , basement membrane , pathogenesis , extracellular matrix , antigen , medicine , chemistry , immunology , microbiology and biotechnology , biology
Abstract Antibody synthesis by the arthritic synovium of rabbits with antigen‐induced arthritis has been demonstrated, but knowledge of the details of the specific localization of antibody in the membrane is limited. Specific antibody in the synovium of ferritin‐induced arthritis was detected by electron microscopic observation of bound ferritin. The specific antibodies were localized in the cisternae of the endoplasmic reticulum and perinuclear spaces within plasma cells. In the extracellular matrix, specific antibody was found distributed as a network within collagen bundles and in the basement membrane of the subsynovial small blood vessels.