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Age‐related changes in bone in the dog: Calcium homeostasis
Author(s) -
Williams E. Alan,
Kelly Patrick J.
Publication year - 1984
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1002/jor.1100020103
Subject(s) - medicine , endocrinology , parathyroid hormone , bone resorption , homeostasis , resorption , calcium metabolism , concomitant , calcium , bone remodeling , hormone , chemistry
To explore the changes in the relationship between skeletal and Ca 2+ homeostasis with age, we studied 50 dogs divided into four age groups. The skeletal uptake of 85 Sr decreased markedly with age, and the immunoreactive parathyroid hormone (iPTH) level increased. There was a significant correlation between iPTH value and the calculated short‐term exchange of Ca in bone (r = −0.55; p < 0.001). Bone formation and bone resorption decreased with age except that in the oldest group of dogs the resorption increased (p < 0.001). We suggest that in aging dogs the skeletal exchange of Ca falls to a very low level that decreases the immediate effect of PTH and thus leads to a chronic net increase in circulating PTH. Concomitant with this is an increase in osteoclastic bone resorption and, over a long time, loss of skeletal mass.