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Isolation of dimeric nonactic acid from the nonactin‐producing Streptomyces spec. JA 5909‐1
Author(s) -
Fleck Werner F.,
Ritzau Michael,
Heinze Stephan,
Gräfe Udo
Publication year - 1996
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.3620360405
Subject(s) - biosynthesis , chemistry , monomer , stereochemistry , streptomyces , electrospray mass spectrometry , antifungal , mass spectrometry , electrospray , biochemistry , organic chemistry , bacteria , chromatography , biology , enzyme , microbiology and biotechnology , genetics , polymer
The formation of possible intermediates of nonactin (I) biosynthesis by Streptomyces spec. JA 5909‐1 was investigated. In addition to monomer nonactic acid (II), the dimeric nonactic acid (III) was isolated suggesting that III could be an intermediate of nonactin biosynthesis. The structure of III was settled by electrospray mass‐spectrometry and high‐field FT‐NMR methods. III displays no antibacterial and antifungal activities supporting the view that cation complex formation by nactin‐type antibiotics requires the entire macrotetrolide ring.