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Effect of immune serum, an antibiotic, and a corticosteroid used alone or in combination on experimental leptospirosis in Mongolian gerbils ( Meriones unguiculatus )
Author(s) -
Yukawa M.,
Kamata H.,
Ohba S.,
Kadoi K.,
Mochizuki K.
Publication year - 1994
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.3620340110
Subject(s) - leptospirosis , penicillin , antibiotics , corticosteroid , immune system , procaine , biology , medicine , pharmacology , immunology , microbiology and biotechnology , veterinary medicine
The results suggest that the combined used of immune serum and corticosteroid (pledonizoron: PZ) inhibits the effects of serum and the marked effects of antibiotic (procaine penicillin‐G: PC‐G) on leptospirosis. PZ had no effects and rather shortened the survival period. PZ did not affect the effects of PC‐G when used in combination. These results suggest that treatment of leptospirosis with corticosteroids requires special caution.