Premium
A correlation with type of sulfonamide resistance gene in Escherichia coli and synergy between trimethoprim and sulfamethoxazole
Author(s) -
Valentine Carrie R.,
Hawk James M.,
Christian Mary M.,
Youmans Roger W.
Publication year - 1992
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.3620320309
Subject(s) - plasmid , escherichia coli , sulfonamide , trimethoprim , sulfamethoxazole , microbiology and biotechnology , gene , enterobacteriaceae , chemistry , biology , strain (injury) , genetics , stereochemistry , antibiotics , anatomy
Plasmids carrying type I or II sulfonamide‐resistance (Su r ) genes were evaluated for their effect on synergy between trimethoprim (Tmp) and sulfamethoxyzole (Smx) in E. coli. Strain J53 containing each of three plasmids (R1, pSa , and R388) with the type I Su r gene displayed a synergistic response to Tmp/Smx; strain LE392 containing a plasmid (RSF1010) with the type II Su r gene displayed no synergy. The difference in synergy between type I and type II Su r genes might be explained by the difference in amount of resistant enzyme produced.