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On the role of 26‐deoxylaidlomycin in laidlomycin biosynthesis
Author(s) -
Gräfe U.,
Stengel C.
Publication year - 1991
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.3620310414
Subject(s) - biosynthesis , mycelium , oxidoreductase , sonication , biochemistry , chemistry , biology , enzyme , botany , chromatography
3 H‐26‐deoxylaidlomycin (I) was fed to growing cultures of Streptoverticillium olivoreticuli IMET 43782 producing both I and laidlomycin (II). The incorporation of labelled I into laidlomycin II was neglible showing a role of I as precursor of II to be at variance. Otherwise, a measurable conversion was achieved by the use of sonicated 48 hrs mycelium suggesting that final oxidation of I to II could be mediated by a compartmentized oxidoreductase.