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Cellular role of DNA polymerase I
Author(s) -
Savic Dragutin J.,
Jankovic Mila,
Kostic Tatjana
Publication year - 1990
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.3620301017
Subject(s) - dna polymerase , dna polymerase ii , dna replication , polymerase , biology , dna polymerase delta , dna polymerase i , dna clamp , mutagenesis , genetics , microbiology and biotechnology , dna , mutation , gene , polymerase chain reaction , reverse transcriptase
Escherichia coli possesses three well‐established DNA polymerases, I, II and III. DNA polymerase I (Pol 1) is the main repair polymerase in E. coli and also has a minor but important role in chromosomal replication. A major advantage of Pol I as an experimental system is its simplicity: unlike other replication enzymes, it is active as a single subunit. To a large extent, mutagenesis appears to be the result of (dis) functions of the DNA replication machinery. It is the purpose of this review to provide an integrated view of this relationship with particular emphasis on the role of Pol I in mutagenic events.