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Instability of in vitro resistance to imipenem in Pseudomonas aeruginosa
Author(s) -
Wolter ErnstJürgen,
Witte Wolfgang
Publication year - 1990
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.3620300823
Subject(s) - imipenem , pseudomonas aeruginosa , microbiology and biotechnology , in vitro , bacterial outer membrane , pseudomonadales , strain (injury) , pseudomonadaceae , biology , pseudomonas , bacteria , chemistry , biochemistry , escherichia coli , gene , genetics , anatomy
In 3 from 19 clinical isolates of Pseudomonas aeruginosa imipenem‐resistant subpopulations could be detected in vitro . In comparison to their wild strains these imipenem‐resistant cells were lacking an outer‐membrane‐protein of 50 kD. In the subpopulation derived from Pseudomonas aeruginosa 76 resistance to imipenem was found to be instable. It could be lost within a short period of time after subcultivation in the absence of imipenem. Cells with restored sensitivity to imipenem possess the outer membrane protein of 50 kD as the wild strain does.