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Microbial synthesis of metabolites with antihypertensive activity: Aspects of fermentation derived inhibitors of angiotensin‐converting enzyme (ACE)
Author(s) -
Manthey Anna,
Reuter Gerhard
Publication year - 1989
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.3620290915
Subject(s) - enzyme , fermentation , angiotensin converting enzyme , biochemistry , chemistry , renin–angiotensin system , peptidyl dipeptidase a , enzyme inhibitor , biology , endocrinology , blood pressure
In this review the microbial angiotensin‐converting enzyme inhibitors are described. Especially from the microbiological point of view the characteristics of these metabolites are given, e.g. occurence, fermentation physiology and specificity. Besides these data, the structure, assays and some isolation problems are summarised. Apart from ACE inhibition the different biological activities of these secondary metabolites are discussed.