Premium
Experimentelle Untersuchungen zur in vitro ‐IFN‐Induktion durch verschiedene Polynucleotide in humanen Zellkultur‐Systemen
Author(s) -
Glück B.,
Meister W.V.,
Witkowski W.,
Stelzner A.,
Hoffmann S.
Publication year - 1988
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.3620280808
Subject(s) - microbiology and biotechnology , chemistry , biology
Several polynucleotides were tested for interferon induction in comparison with the standard Poly (IC) in human diploid fibroblasts and in human leukocyte suspensions. We received high IFN‐titre following superinduction of the polynucleotides in human fibroblasts. These results show that under superinduction conditions partly 3 times more interferon is induced in comparison with the standard inductor Poly (IC). The tested concentration of 10 μg/ml polynucleotides did not result in any IFN yields or only in very low ones in human leukocytes, which were only within the range of detectability.