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The molecular genetics of copper resistance in Saccharomyces cerevisiae — a paradigm for non‐conventional yeasts
Author(s) -
Fogel Seymour,
Welch Juliet W.,
Maloney Daniel H.
Publication year - 1988
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.3620280302
Subject(s) - saccharomyces cerevisiae , biology , eukaryote , genetics , gene , meiosis , metallothionein , chromosome , copper , molecular genetics , genome , chemistry , organic chemistry
After a short introduction on the historical background of the development of Saccharomyces cerevisiae as a model eukaryote, a review is given on the present state of genetics and molecular biology of copper resistance in S. cerevisiae . The gene CUP1 encodes a protein (copper metallothionein) of a molecular weight of 6570 dalton. The synthesis of this copper chelatin is induced by copper and is regulated at the level of transcription. Copper resistance (CUP r ) is correlated with amplification of CUP1 and resulted in a higher copy number of this gene on chromosome VIII. Spontaneous meiotic alterations of the gene copy number have been studied.