Premium
The role of copper(I)‐nicotinic acid complex on kojic acid biosynthesis by Aspergillus flavus
Author(s) -
Megalla S. E.,
Nassar A. Y.,
Gohar M. A. S.
Publication year - 1987
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.3620270105
Subject(s) - kojic acid , copper , chemistry , nicotinic agonist , aspergillus flavus , biosynthesis , biochemistry , organic chemistry , food science , enzyme , receptor , tyrosinase
Addition of cooper‐monovalent‐nicotinic acid complex to a synthetic medium specific for kojie acid production by Aspergillus flavus enhanced the production by about 47%. The substance is proposed to act via a biochemical utilization of the copper(I)‐B 3 complex in a manner similar to that of the naturally utilized nicotinic acid. NAD and NADP like carriers with higher reactivity have been predicted. According to this prediction the biosynthetic route of kojic acid has been interpreted on the basis of a model proposed by BAJPAI et al. (1981). In this model the enzymes participating are dependent on NAD and NADP (glucose dehydrogenase and gluconate dehydrogenase) as well as on other reduction processes.