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Optimierung von Fermentationsprozessen unter Berücksichtigung struktureller Zusammenhänge im Modell
Author(s) -
Reimann B.
Publication year - 1986
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.3620261008
Subject(s) - computer science , sensitivity (control systems) , process (computing) , function (biology) , biochemical engineering , mathematical optimization , mathematics , biology , engineering , programming language , evolutionary biology , electronic engineering
Using simulation programs for batch secondary metabolite fermentations, I developed a “hybrid” process optimization approach characterized by considering pragmatic aspects related to the theoretical concept as well as methodical aspects regarding experimental experience. Influences and mutual relationships of starting parameters amenable to change are discussed with the aim of defining an efficient strategy of optimization, using a classification scheme for the model parameters employed. Due to mutual and stochastic influences of these parameters, there remain only a few experiments to be carried out, and their number depends on the sensitivity of the gain function to the respective parameter. Some requirements any simulation program must fulfil in order to help optimize fermentation processes are pointed out.