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The production of 3aα‐H‐4α‐(3′‐propionic acid)‐5α‐hydroxy‐7aβ‐methylhexahydro‐1‐indanone‐δ‐lactone by Nocardia restricta mutants
Author(s) -
Miclo A.,
Germain P.,
Lefebvre G.
Publication year - 1986
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.3620260411
Subject(s) - chemistry , mutant , nocardia , lactone , stereochemistry , biochemistry , bacteria , biology , gene , genetics
Two mutants of Nocardia restricta breakdown androst‐4‐ene‐3,17‐dione into 3aα‐H‐4α‐(3′‐propionic acid)‐5α‐hydroxy‐7aβ‐methylhexahydro‐l‐indanone‐δ‐lactone. The metabolic intermediates formed are very different in each mutant. One uses certain aromatic compounds very slowly. A degradation pathway for steroids by Nocardia restricta has been proposed.