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Synergistic effect of cobalt on the induction by A‐factor of the formation of aerial mycelium and anthracyclines by a blocked mutant of Streptomyces griseus
Author(s) -
Gräfe U.,
Eritt I.,
Riesenberg D.
Publication year - 1985
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.3620250413
Subject(s) - streptomyces griseus , mycelium , mutant , metabolite , effector , secondary metabolism , biology , biochemistry , strain (injury) , secondary metabolite , cobalt , metabolism , microbiology and biotechnology , chemistry , streptomyces , biosynthesis , bacteria , botany , genetics , anatomy , gene , inorganic chemistry
Cobalt ions synergistically supported the inducing effect of A‐factor 1a on the formation of aerial mycelium and anthracyclines by the blocked S. griseus mutant 86. This suggested an involvement of effector 1a in the transport or metabolism of this trace element. In accordance with the proposed role of 1a as an autoregulatory secondary metabolite, the parent strain S. griseus JA 3933 secreted 1a into the medium after a decrease of the specific growth rate and before the onset of antibiotic production.