Premium
Influence of nourseothricin on growth and secondary metabolism of Streptomyces noursei JA 3890b
Author(s) -
Röder B.,
Plonka G.,
Bormann E. J.,
Gräfe U.
Publication year - 1985
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.3620250306
Subject(s) - mycelium , spore , secondary metabolite , streptomyces , metabolite , microbiology and biotechnology , strain (injury) , antibiotics , biology , metabolism , actinomycetales , secondary metabolism , bacteria , chemistry , biochemistry , botany , biosynthesis , enzyme , gene , anatomy , genetics
The nourseothricin‐producing S. noursei strain JA 3890 b possessed a high degree of resistance to its own antibiotic when grown in submerged cultures started from mycelium samples as inocula. In contrast, both the outgrowth of spores and the development of surface colonies from mycelium samples were severely inhibited in the presence of relatively low concentrations of nourseothricin, suggesting that the producer organism is susceptible to the autotoxic metabolite in particular stages of its development. Nourseothricin production by submerged cultures has been found to be independent of negative feedback regulation by the antibiotic.