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Assessment of antibacterial and antifungal potential of Curcuma longa and synthesized nanoparticles: A comparative study
Author(s) -
Khan Mansoor Ahmed,
Moghul Nurain Baig,
Butt Maisra Azhar,
Kiyani Mubin Mustafa,
Zafar Ibraheem,
Bukhari Ali Imran
Publication year - 2021
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.202100010
Subject(s) - curcumin , curcuma , antibacterial activity , aspergillus niger , chemistry , nanoparticle , agar diffusion test , nuclear chemistry , escherichia coli , microbiology and biotechnology , traditional medicine , biochemistry , bacteria , biology , nanotechnology , materials science , medicine , gene , genetics
Curcumin nanoparticles were most recently considered in medical research because of their antibacterial properties. The main objective of the study was to develop the green synthesis and antibacterial activity of curcumin nanoparticles using Curcuma longa . The processing of curcumin nanoparticles was carried out after the collection, identification, and extraction of curcumin. The effect of a sample on the synthesis of nanoparticles, such as curcumin aqueous concentrations (5, 10, and 20 mg/ml) and curcumin nanoparticles (5, 10, and 20 mg/ml), and the antibacterial effect of these nanoparticles on Escherichia coli, Staphylococcus aureus , Pseudomonas aeruginosa, Klebsiella pneumoniae , and the fungal strain Aspergillus niger . For examining antibacterial and anti‐fungal activity disc diffusion method was performed, followed by the zone of inhibition. According to X‐ray diffraction and scanning electron microscope analysis, nanoparticles have spherical shapes and size of 42.64 nm. Results showed that a high dose of 20 mg/ml curcumin nanoparticles have more antibacterial activity than curcumin extracts in E. coli as it showed the largest diameter of zone of inhibition as compared to other doses. Other bacterial and fungal strains also showed significant results but E. coli was most prominent. The biosynthesis of curcumin nanoparticles using an aqueous extract of C. longa is a clean, inexpensive, and safe method that has not been used any toxic substance and consequently does not have side effects. Since several pathogenic species have acquired antibiotic resistance, the combination of curcumin with various nanoparticles would be beneficial in the cure of pathogenic diseases.