Cover: Journal of Basic Microbiology. 7/2016

Metabolic pathways putatively involved in copper response of Candida fukuyamaensis . When the yeast is cultured in the presence of elevated copper concentrations it is able to interact with the metal and incorporate it through high or low affinity Cu ion uptake systems. Copper is reduced from Cu+2 to Cu+1 by cell surface reductases prior to uptake. Alternatively, endocytosis by, e.g., eisosomes (Lsp1) is possible. Within the cell, Cu is bound to cytosolic Cu chaperones such as Ccs for specific delivery to enzymes such as superoxide dismutase, Sod1. Free, unbound Cu can interact with oxygen in the cytoplasm promoting generation or reactive oxygen species (ROS). ROS then triggers defense with protein synthesis (Eft2), as peroxiredoxines (Prx1), chaperones (Ssb1), etc. Oxidized proteins are tagged by ubiquitin (Ubi1) for proteosome degradation. Finally, protein biosynthesis and vesicular traffic would explain the elevated energy demand (Tpi1, Gpm1, G3pdh, Eno1). (Figure: Verónica Irazusta, Instituto de Investigaciones para la Industria Química, INIQUI‐CONICET, Universidad Nacional de Salta (UNSa), Salta, Argentina).