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Strain improvement of industrially important microorganisms based on resistance to toxic metabolites and abiotic stress
Author(s) -
Fiedurek Jan,
Trytek Mariusz,
Szczodrak Janusz
Publication year - 2017
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.201600710
Subject(s) - microorganism , strain (injury) , abiotic component , biochemical engineering , microbiology and biotechnology , biology , mutant , chemistry , bacteria , biochemistry , engineering , ecology , genetics , gene , anatomy
Improvement of the biosynthetic capabilities of industrially relevant microbes to produce desired metabolites in higher quantities is one of the important topics of modern biotechnology. In this article, different strategies of improvement of mutated microbial strains are briefly described. This is followed by the first comprehensive review of the literature on obtaining high yielding microorganisms, that is, mutants exhibiting resistance to antimetabolites, nutritional repression, and abiotic stresses as well as tolerance to solvents and toxic substrates or products. Furthermore, the efficiency of the microbial metabolites produced by improved microbial strains, advantages, and limitations, as well as future prospects for strategies of strain development are discussed.