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Two‐component signal transduction system SaeRS is involved in competence and penicillin susceptibility in Staphylococcus epidermidis
Author(s) -
Lou Qiang,
Ma Yuanfang,
Qu Di
Publication year - 2016
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.201500488
Subject(s) - staphylococcus epidermidis , penicillin , microbiology and biotechnology , signal transduction , staphylococcus , chemistry , staphylococcus aureus , biology , bacteria , biochemistry , antibiotics , genetics
Staphylococcus epidermidis , which is a causative pathogen of nosocomial infection, expresses its virulent traits such as biofilm and autolysis regulated by two‐component signal transduction system SaeRS. In this study, the S. epidermidis SaeRS was identified to negatively regulate the expression of genes involved in competence (comF, murF), cytolysis (lrgA), and autolysis (lytS) by DNA microarray or real‐time RT–PCR analysis. In addition, saeRS mutant showed increased competence and higher susceptibility to antibiotics such as penicillin and oxacillin than the wild‐type strain. The study will be helpful for understanding the characterization of the SaeRS in S. epidermidis .