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Redox sensing and signaling by malaria parasite in vertebrate host
Author(s) -
Tripathy Satyajit,
Roy Somenath
Publication year - 2015
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.201500031
Subject(s) - reactive oxygen species , oxidative stress , plasmodium (life cycle) , microbiology and biotechnology , malaria , biology , reactive nitrogen species , redox , vacuole , radical , host (biology) , protozoa , parasite hosting , biochemistry , chemistry , immunology , ecology , cytoplasm , organic chemistry , world wide web , computer science
Plasmodium parasites, which is responsible to cause malaria, are also exceedingly receptive to oxidative stress during their intraerythrocytic life stage as they devour haemoglobin inside their food vacuoles and engender toxic haem moieties and reactive oxygen species (ROS). Other than, several studies suggest that the generation of reactive oxygen and nitrogen species (ROS and RNS) associated with oxidative stress, plays a decisive role in the ripeness of systemic complications caused by malaria. Malaria infection provokes the generation of hydroxyl radicals (OH • ), which most probably is the main reason for the induction of oxidative stress and apoptosis. In this study, it has been described to understand how redox molecules and NO carry out their diverse functions in both parasites and host. It is very important to understand the chemical reactions that produce those outcomes and how its regulation carried out by parasite during erythrocytic phase.