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Peptide profiling of the route from Mahoney to Sabin, and return
Author(s) -
Kanduc Darja,
Fasano Candida,
Bavaro Simona Lucia,
Novello Giuseppe,
Lucchese Guglielmo,
Capone Giovanni
Publication year - 2014
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.201200642
Subject(s) - poliovirus , poliomyelitis , virology , strain (injury) , biology , peptide sequence , virus , genetics , gene , anatomy
ABSTRACT In order to define poliovirus (PV) neurovirulence at the molecular level, we comparatively analyze the primary amino acid sequence of Mahoney, a neurovirulent PV strain, versus (i) Sabin, an attenuated PV strain, and (ii) IS1, a PV isolate obtained in temporal association to a paralysis event from a polio vaccinated subject. We identify and describe 12 pentapeptides that, originally present in the Mahoney sequence, are changed in the non‐neurovirulent Sabin strain, and, successively, restored in IS1 strain.