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Genomic comparisons between paired bacterial strains with strong and weak GC skews
Author(s) -
Song TieJun,
Wang Yue,
Shen JianGen,
Pan JianPing,
Huang Jun
Publication year - 2014
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.201200252
Subject(s) - buchnera , skew , biology , genome , genetics , bacterial genome size , gc content , mycoplasma , gene , physics , astronomy
A majority of known eubacterial genomes are characteristic of GC skew, i.e., the leading strand has exceeding number of G over C. The cause of this compositional bias is still not very clear. In this study, we chose five pairs of genomes from distantly related bacterial genera, i.e., Buchnera , Haemophilus , Mycoplasma , Mycobacterium , and Synechococcus , each containing one with strong GC skew and the other with weak GC skew. Through comparison of the orthologous genes in these genera, we found that neither chromosomal rearrangement nor CDS skew has direct relationship with GC skew.